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Catalog No.: 611936
Cas No.: 108212-75-5
Purity : 98% 
611936 - Calicheamicin | CAS 108212-75-5

Catalog number : 611936

CAS number : 108212-75-5

Molecular Formula : C55H74IN3O21S4 

Molecular Weight : 1368.35 

Iupac Chemical Name : Calicheamicin 

InChiKey :

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SynonymsCalicheamicin ��1 
Molecular FormulaC55H74IN3O21S4 
Molecular Weight1368.35 
Appearancecrystalline solid 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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Calicheamicin is a potent DNA-binding cytotoxic antibiotic.

Calicheamicin being the most notable enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora. Calicheamicin targets DNA and cause strand scission. Calicheamicin binds with DNA in the minor groove, wherein they then undergo a reaction analogous to the Bergman cyclization to generate a diradical species. This diradical, 1,4-didehydrobenzene, then abstracts hydrogen atoms from the deoxyribose (sugar) backbone of DNA, which ultimately leads to strand scission. The specificity of binding of Calicheamicin to the minor groove of DNA was demonstrated to be due to the aryltetrasaccharide group of the molecule.


108212-75-5 - Request Bulk Quote

108212-75-5 - Request Bulk Quote