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Calicheamicin

Catalog No.: 611936
Cas No.: 108212-75-5
Purity : 98% 

Calicheamicin is a potent DNA-binding cytotoxic antibiotic.


Calicheamicin being the most notable enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora. Calicheamicin targets DNA and cause strand scission. Calicheamicin binds with DNA in the minor groove, wherein they then undergo a reaction analogous to the Bergman cyclization to generate a diradical species. This diradical, 1,4-didehydrobenzene, then abstracts hydrogen atoms from the deoxyribose (sugar) backbone of DNA, which ultimately leads to strand scission. The specificity of binding of Calicheamicin to the minor groove of DNA was demonstrated to be due to the aryltetrasaccharide group of the molecule.



 

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Chemical Information

NameCalicheamicin
Iupac Chemical NameCalicheamicin 
SynonymsCalicheamicin ��1 
Molecular FormulaC55H74IN3O21S4 
Molecular Weight1368.35 
InChiKey
InChi
CAS Number108212-75-5
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

611936 - Calicheamicin | CAS 108212-75-5

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