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Cabozantinib

Catalog No.: 52777
Cas No.: 849217-68-1
Purity : 98% 
52777 - Cabozantinib | CAS 849217-68-1

Catalog number : 52777

CAS number : 849217-68-1

Molecular Formula : C28H24FN3O5 

Molecular Weight : 501.51 

Chemical Name : Cabozantinib

Smile : COc1cc2c(ccnc2cc1OC)Oc3ccc(cc3)NC(=O)C4(CC4)C(=O)Nc5ccc(cc5)F

InChiKey : ONIQOQHATWINJY-UHFFFAOYSA-N

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Molecular FormulaC28H24FN3O5 
Molecular Weight501.51 
Purity98% 
SolubilityDMSO ��114mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL 
SmileCOc1cc2c(ccnc2cc1OC)Oc3ccc(cc3)NC(=O)C4(CC4)C(=O)Nc5ccc(cc5)F
InChiKeyONIQOQHATWINJY-UHFFFAOYSA-N
InChiInChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
MDLMFCD20926324
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Cabozantinib (XL184, BMS-907351) is a potent VEGFR2 inhibitor with IC50 of 0.035 nM and also inhibits c-Met, Ret, Kit, Flt-1/3/4, Tie2, and AXL with IC50 of 1.3 nM, 4 nM, 4.6 nM, 12 nM/11.3 nM/6 nM, 14.3 nM and 7 nM, respectively 

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