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CX-5461

Catalog No: 52748
CAS Number: 1138549-36-6
Purity: 98% 

CX-5461 is an inhibitor of rRNA synthesis, selectively inhibits Pol I-driven transcription of rRNA with IC50 of 142 nM, has no effect on Pol II, and possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation. 

For research use only. We do not sell to patients.

Chemical Information

NameCX-5461
Molecular FormulaC27H27N7O2S 
Molecular Weight513.61 
SmileCc1cnc(cn1)CNC(=O)c2c(=O)c3ccc(nc3n4c2sc5c4cccc5)N6CCCN(CC6)C
InChiKeyXGPBJCHFROADCK-UHFFFAOYSA-N
InChiInChI=1S/C27H27N7O2S/c1-17-14-29-18(15-28-17)16-30-26(36)23-24(35)19-8-9-22(33-11-5-10-32(2)12-13-33)31-25(19)34-20-6-3-4-7-21(20)37-27(23)34/h3-4,6-9,14-15H,5,10-13,16H2,1-2H3,(H,30,36)
CAS Number1138549-36-6
MDLMFCD21609261
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Ordering Information

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Purity98% 
SolubilityDMSO <1.2mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL 
Handling
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

52748 - CX-5461 | CAS 1138549-36-6

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