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CX-4945(Silmitasertib)

Catalog No: 52024
CAS Number: 1009820-21-6
Purity: 98% 

Silmitasertib (CX-4945) is a potent and selective orally bioavailable small molecule inhibitor of Casein kinase II (CK2). The antiproliferative activity of CX-4945 against cancer cells correlated with expression levels of the CK2α catalytic subunit. CX-4945 caused cell-cycle arrest and selectively induced apoptosis in cancer cells relative to normal cells. 

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Chemical Information

NameCX-4945(Silmitasertib)
Iupac Chemical Name5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid 
SynonymsCX-4945;Silmitasertib;CX4945;CX 4945 
Molecular FormulaC19H12ClN3O2 
Molecular Weight349.77 
SmileClC=1C=C(C=CC1)NC1=NC2=C(C3=CN=CC=C13)C=CC(=C2)C(=O)O
InChiKeyMUOKSQABCJCOPU-UHFFFAOYSA-N
InChiInChI=1S/C19H12ClN3O2/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18/h1-10H,(H,22,23)(H,24,25)
CAS Number1009820-21-6
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationyellow solid 
Purity98% 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
Solubility5mg/ml in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

52024 - CX-4945(Silmitasertib) | CAS 1009820-21-6

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