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CVT-313

Catalog No.: 16122923
Cas No.: 199986-75-9
Purity : 98% 
16122923 - CVT-313 | CAS 199986-75-9

Catalog number : 16122923

CAS number : 199986-75-9

Molecular Formula : C20H28N6O3 

Molecular Weight : 400.483 

Iupac Chemical Name : CVT-313 

Smile : CC(C)n1cnc2c1nc(nc2NCc3ccc(cc3)OC)N(CCO)CCO

InChiKey : NQVIIUBWMBHLOZ-UHFFFAOYSA-N

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SynonymsCVT 313; CVT313 
Molecular FormulaC20H28N6O3 
Molecular Weight400.483 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCC(C)n1cnc2c1nc(nc2NCc3ccc(cc3)OC)N(CCO)CCO
InChiKeyNQVIIUBWMBHLOZ-UHFFFAOYSA-N
InChiInChI=1S/C20H28N6O3/c1-14(2)26-13-22-17-18(21-12-15-4-6-16(29-3)7-5-15)23-20(24-19(17)26)25(8-10-27)9-11-28/h4-7,13-14,27-28H,8-12H2,1-3H3,(H,21,23,24)
MDLMFCD06411412
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CVT-313 is a potent and selective inhibitor of CDK2 that prevents neointimal proliferation. CVT-313 has an IC50 of 0.5 microM in vitro. Inhibition was competitive with respect to ATP (Ki = 95 nM), and selective CVT-313 had no effect on other, nonrelated ATP-dependent serine/threonine kinases. The growth of mouse, rat, and human cells in culture was also inhibited by CVT-313 with the IC50 for growth arrest ranging from 1.25 to 20 microM. CVT-313 is a promising candidate for evaluation in other disease models related to aberrant cell proliferation. 

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