CHZ868(CHZ-868)
Catalog No: 72001
CAS Number: 1895895-38-1
Purity: 98% by HPLC
CHZ868,a type II JAK inhibitor, would demonstrate activity in JAK inhibitor persistent cells, murine MPN models, and MPN patient samples. JAK2 and MPL mutant cell lines were sensitive to CHZ868, including type I JAK inhibitor persistent cells. CHZ868 showed significant activity in murine MPN models and induced reductions in mutant allele burden not observed with type I JAK inhibitors. These data demonstrate that type II JAK inhibition is a viable therapeutic approach for MPN patients.
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Chemical Information
| Name | CHZ868(CHZ-868) |
|---|---|
| Iupac Chemical Name | N-(4-((2-((2,4-difluorophenyl)amino)-1,4-dimethyl-1H-benzo[d]imidazol-5-yl)oxy)pyridin-2-yl)acetamide |
| Synonyms | CHZ 868;CHZ-868;CHZ868 |
| Molecular Formula | C22H19F2N5O2 |
| Molecular Weight | 423.42 |
| Smile | CN1C2=CC=C(OC3=CC=NC(NC(C)=O)=C3)C(C)=C2N=C1NC4=CC=C(F)C=C4F |
| InChiKey | KQQLBXFPTDVFAJ-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H19F2N5O2/c1-12-19(31-15-8-9-25-20(11-15)26-13(2)30)7-6-18-21(12)28-22(29(18)3)27-17-5-4-14(23)10-16(17)24/h4-11H,1-3H3,(H,27,28)(H,25,26,30) |
| CAS Number | 1895895-38-1 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% by HPLC |
| Storage | 3 years -20ºCpowder 6 months-80ºCin solvent |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
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