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CHIR-99021

Catalog No.: 16062904
Cas No.: 252917-06-9
Purity : 98% by HPLC 
16062904 - CHIR-99021 | CAS 252917-06-9

Catalog number : 16062904

CAS number : 252917-06-9

Molecular Formula : C22H18Cl2N8 

Molecular Weight : 465.34 

Iupac Chemical Name : 6-((2-((4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile 

Smile : ClC1=C(C=CC(=C1)Cl)C1=NC(=NC=C1C=1NC=C(N1)C)NCCNC1=NC=C(C#N)C=C1

InChiKey : AQGNHMOJWBZFQQ-UHFFFAOYSA-N

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SynonymsCHIR99021; CHIR-99021 
Molecular FormulaC22H18Cl2N8 
Molecular Weight465.34 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileClC1=C(C=CC(=C1)Cl)C1=NC(=NC=C1C=1NC=C(N1)C)NCCNC1=NC=C(C#N)C=C1
InChiKeyAQGNHMOJWBZFQQ-UHFFFAOYSA-N
InChiInChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32)
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CHIR-99021, also known as CT99021, is a glycogen synthase kinase 3 (GSK3) inhibitor that has antiproliferative activity in vitro and in vivo. CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10M 

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