CHIR-99021, also known as CT99021, is a glycogen synthase kinase 3 (GSK3) inhibitor that has antiproliferative activity in vitro and in vivo. CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10M
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