CHIR-99021
Catalog No: 16062904
CAS Number: 252917-06-9
Purity: 98% by HPLC
CHIR-99021, also known as CT99021, is a glycogen synthase kinase 3 (GSK3) inhibitor that has antiproliferative activity in vitro and in vivo. CHIR-99021 inhibits GSK-3 with IC50 at 7 nM. In a series of carcinoma cell lines, the IC50 of CHIR99021 for proliferation is about 10M
For research use only. We do not sell to patients.
Chemical Information
| Name | CHIR-99021 |
|---|---|
| Iupac Chemical Name | 6-((2-((4-(2,4-dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile |
| Synonyms | CHIR99021; CHIR-99021 |
| Molecular Formula | C22H18Cl2N8 |
| Molecular Weight | 465.34 |
| Smile | ClC1=C(C=CC(=C1)Cl)C1=NC(=NC=C1C=1NC=C(N1)C)NCCNC1=NC=C(C#N)C=C1 |
| InChiKey | AQGNHMOJWBZFQQ-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H18Cl2N8/c1-13-10-29-21(31-13)17-12-30-22(32-20(17)16-4-3-15(23)8-18(16)24)27-7-6-26-19-5-2-14(9-25)11-28-19/h2-5,8,10-12H,6-7H2,1H3,(H,26,28)(H,29,31)(H,27,30,32) |
| CAS Number | 252917-06-9 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
