CHIR-98014
Catalog No: 5121103
CAS Number: 252935-94-7
Purity: 98% by HPLC
CHIR98014 is a reversible, cell-permeable activator of the WNT pathway, through inhibition of both isoforms of glycogen synthase kinase 3 (GSK3 and GSK3) with IC₅₀ values of 0.65 and 0.58 nM, respectively. It shows at least 500-fold selectivity for GSK-3 versus 20 other serine/threonine or tyrosine kinases (Ring et al.).
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Chemical Information
| Name | CHIR-98014 |
|---|---|
| Iupac Chemical Name | N6-[ 2-[4-(2,4-DICHLORO-PHENYL)-5-IMIDAZOL-1-YL-PYRIMIDIN-2-YLAMINO]-ETHYL]-3-NITRO-PYRIDINE-2,6-DIAMINE |
| Synonyms | CHIR98014;CHIR 98014 |
| Molecular Formula | C20H17Cl2N9O2 |
| Molecular Weight | 486.31 |
| Smile | NC1=NC(NCCNC2=NC=C(N3C=CN=C3)C(C4=CC=C(Cl)C=C4Cl)=N2)=CC=C1[N+]([O-])=O |
| InChiKey | MDZCSIDIPDZWKL-UHFFFAOYSA-N |
| InChi | InChI=1S/C20H17Cl2N9O2/c21-12-1-2-13(14(22)9-12)18-16(30-8-7-24-11-30)10-27-20(29-18)26-6-5-25-17-4-3-15(31(32)33)19(23)28-17/h1-4,7-11H,5-6H2,(H3,23,25,28)(H,26,27,29) |
| CAS Number | 252935-94-7 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | crystalline solid |
|---|---|
| Purity | 98% by HPLC |
| Storage | 3 years -20ºCpowder;6 months-80ºCin solvent |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
