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CH5132799 (PA-799)

Catalog No.: 160926015
Cas No.: 1007207-67-1
Purity : 98% by HPLC 
160926015 - CH5132799 (PA-799) | CAS 1007207-67-1

Catalog number : 160926015

CAS number : 1007207-67-1

Molecular Formula : C15H19N7O3S 

Molecular Weight : 377.42146 

Iupac Chemical Name : 5-(7-(methylsulfonyl)-2-morpholino-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine 

Smile : CS(=O)(=O)N1CCC2=C1N=C(N=C2C=2C=NC(=NC2)N)N2CCOCC2

InChiKey : JEGHXKRHKHPBJD-UHFFFAOYSA-N

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SynonymsCH5132799; CH-5132799; CH 5132799; PA-799; PA799; PA-799. 
Molecular FormulaC15H19N7O3S 
Molecular Weight377.42146 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileCS(=O)(=O)N1CCC2=C1N=C(N=C2C=2C=NC(=NC2)N)N2CCOCC2
InChiKeyJEGHXKRHKHPBJD-UHFFFAOYSA-N
InChiInChI=1S/C15H19N7O3S/c1-26(23,24)22-3-2-11-12(10-8-17-14(16)18-9-10)19-15(20-13(11)22)21-4-6-25-7-5-21/h8-9H,2-7H2,1H3,(H2,16,17,18)
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CH5132799, also known as PA-799, is a novel class I PI3K inhibitor, which exhibited a strong inhibitory activity especially against PI3K (IC(50)=0.014 M). In human tumor cell lines with PI3K pathway activation, CH5132799 showed potent antiproliferative activity. CH5132799 is orally available and showed significant antitumor activity in PI3K pathway-activated human cancer xenograft models in mice. CH5132799 selectively inhibited class I PI3Ks and PI3K mutants in in vitro kinase assays. Tumors harboring PIK3CA mutations were significantly sensitive to CH5132799 in vitro and were remarkably regressed by CH5132799 in in vivo mouse xenograft models. 

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