CFT1946
Catalog No: 25078
CAS Number: 2882165-79-7
Purity: ≧98.0%
CFT1946 is an investigational, orally bioavailable small molecule degrader of BRAF V600 mutations in solid tumors currently being evaluated in a Phase 1/2 global clinical trial in patients refractory to BRAF inhibitors.
For research use only. We do not sell to patients.
Chemical Information
| Name | CFT1946 |
|---|---|
| Iupac Chemical Name | (3R)-3-[6-[2-cyano-3-[[ethyl(methyl)sulfamoyl]amino]-6-fluorophenoxy]-4-oxoquinazolin-3-yl]-8-[2-[1-[3-(2,4-dioxo-1,3-diazinan-1-yl)-5-fluoro-1-methylindazol-6-yl]-4-hydroxypiperidin-4-yl]acetyl]-1-oxa-8-azaspiro[4.5]decane |
| Synonyms | CFT-1946 ; CFT 1946 ; CFT1946 |
| Molecular Formula | C45H49F2N11O9S |
| Molecular Weight | 958.01 |
| Smile | O=C(N(CC1)CCC21C[C@@H](N3C=NC4=C(C=C(OC5=C(F)C=CC(NS(=O)(N(CC)C)=O)=C5C#N)C=C4)C3=O)CO2)CC6(O)CCN(C7=CC8=C(C=C7F)C(N9C(NC(CC9)=O)=O)=NN8C)CC6 |
| InChiKey | OCDRMYDQTIPVOI-HHHXNRCGSA-N |
| InChi | InChI=1S/C45H49F2N11O9S/c1-4-53(2)68(64,65)52-35-8-6-32(46)40(31(35)24-48)67-28-5-7-34-29(19-28)42(61)58(26-49-34)27-22-45(66-25-27)12-17-56(18-13-45)39(60)23-44(63)10-15-55(16-11-44)37-21-36-30(20-33(37)47)41(51-54(36)3)57-14-9-38(59)50-43(57)62/h5-8,19-21,26-27,52,63H,4,9-18,22-23,25H2,1-3H3,(H,50,59,62)/t27-/m1/s1 |
| CAS Number | 2882165-79-7 |
| Related CAS | 2882165-79-7 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Light-yellow solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
