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CF-102

Catalog No.: 16053104
Cas No.: 163042-96-4
Purity : 98% by HPLC 

CF-102, also known as 2-Cl-IB-MECA, is an orally bioavailable, synthetic, highly selective adenosine A3 receptor (A3AR) agonist with potential antineoplastic activity. Adenosine A3 receptor agonist CF102 selectively binds to and activates the cell surface-expressed A3AR, deregulating Wnt and NF-kB signal transduction pathways downstream, which may result in apoptosis of A3AR-expressing tumor cells. A3AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of various solid tumor cell types, including hepatocellular carcinoma (HCC) cells, and plays an important role in cellular proliferation 

For research use only. We do not sell to patients.

Chemical Information

NameCF-102
Iupac Chemical Name(2S,3S,4R,5R)-5-(2-chloro-6-((3-iodobenzyl)amino)-9H-purin-9-yl)-3,4-dihydroxy-N-methyltetrahydrofuran-2-carboxamide 
SynonymsCF 102; Cl-IB-MECA; 2-Cl-IB-MECA 
Molecular FormulaC18H18ClIN6O4 
Molecular Weight544.73079 
SmileClC1=NC(=C2N=CN(C2=N1)[C@H]1[C@@H]([C@@H]([C@H](O1)C(=O)NC)O)O)NCC1=CC(=CC=C1)I
InChiKeyIPSYPUKKXMNCNQ-PFHKOEEOSA-N
InChiInChI=1S/C18H18ClIN6O4/c1-21-16(29)13-11(27)12(28)17(30-13)26-7-23-10-14(24-18(19)25-15(10)26)22-6-8-3-2-4-9(20)5-8/h2-5,7,11-13,17,27-28H,6H2,1H3,(H,21,29)(H,22,24,25)/t11-,12+,13-,17+/m0/s1
CAS Number163042-96-4
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Ordering Information

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FormulationSolid powder 
Purity98% by HPLC 
Storage-20 ºC for 3 years 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16053104 - CF-102 | CAS 163042-96-4

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