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CEP-40783

Catalog No.: 186281
Cas No.: 1437321-24-8
Purity : >98%
186281 - CEP-40783 | CAS 1437321-24-8

Catalog number : 186281

CAS number : 1437321-24-8

Molecular Formula : C31H26F2N4O6

Molecular Weight : 588.56

Iupac Chemical Name : N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-3-(4-fluorophenyl)-2,4-dioxo-1-propan-2-ylpyrimidine-5-carboxamide

Smile : O=C(C1=CN(C(C)C)C(N(C2=CC=C(F)C=C2)C1=O)=O)NC3=CC=C(OC4=CC=NC5=CC(OC)=C(OC)C=C45)C(F)=C3

InChiKey : FKCWHHYUMFGOPY-UHFFFAOYSA-N

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SynonymsCEP-40783; CEP40783; CEP 40783; RXDX-106; RXDX 106; RXDX106.
Molecular FormulaC31H26F2N4O6
Molecular Weight588.56
AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
SmileO=C(C1=CN(C(C)C)C(N(C2=CC=C(F)C=C2)C1=O)=O)NC3=CC=C(OC4=CC=NC5=CC(OC)=C(OC)C=C45)C(F)=C3
InChiKeyFKCWHHYUMFGOPY-UHFFFAOYSA-N
InChiInChI=1S/C31H26F2N4O6/c1-17(2)36-16-22(30(39)37(31(36)40)20-8-5-18(32)6-9-20)29(38)35-19-7-10-26(23(33)13-19)43-25-11-12-34-24-15-28(42-4)27(41-3)14-21(24)25/h5-17H,1-4H3,(H,35,38)
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CEP-40783, also known as RXDX-106, is a potent, selective and orally available inhibitor of AXL and c-Met with IC50 values of 7 nM and 12 nM, respectively for use in breast, non-small cell lung (NSCLC), and pancreatic cancers.

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