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CEP-32496

Catalog No.: 110229
Cas No.: 1188910-76-0
Purity : 98% 
110229 - CEP-32496 | CAS 1188910-76-0

Catalog number : 110229

CAS number : 1188910-76-0

Molecular Formula : C24H22F3N5O5 

Molecular Weight : 517.46 

Iupac Chemical Name : 1-[3-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-[5-(1,1,1-trifluoro-2-methylpropan-2-yl)-1,2-oxazol-3-yl]urea 

Smile : CC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F

InChiKey : DKNUPRMJNUQNHR-UHFFFAOYSA-N

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SynonymsCEP 32496; CEP32496 
Molecular FormulaC24H22F3N5O5 
Molecular Weight517.46 
AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileCC(C)(C1=CC(=NO1)NC(=O)NC2=CC(=CC=C2)OC3=NC=NC4=CC(=C(C=C43)OC)OC)C(F)(F)F
InChiKeyDKNUPRMJNUQNHR-UHFFFAOYSA-N
InChiInChI=1S/C24H22F3N5O5/c1-23(2,24(25,26)27)19-11-20(32-37-19)31-22(33)30-13-6-5-7-14(8-13)36-21-15-9-17(34-3)18(35-4)10-16(15)28-12-29-21/h5-12H,1-4H3,(H2,30,31,32,33)
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CEP-32496 is a highly potent inhibitor of BRAF(V600E/WT) and c-Raf with Kd of 14 nM/36 nM and 39 nM, also potent to Abl-1, c-Kit, Ret, PDGFR_beta_ and VEGFR2, respectively; insignificant affinity for MEK-1, MEK-2, ERK-1 and ERK-2. 

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