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CCT244747

Catalog No.: 16070913
Cas No.: 1404095-34-6
Purity : 98% by HPLC 
16070913 - CCT244747 | CAS 1404095-34-6

Catalog number : 16070913

CAS number : 1404095-34-6

Molecular Formula : C20H24N8O2 

Molecular Weight : 408.46 

Iupac Chemical Name : (R)-3-((1-(dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile 

Smile : CN(C[C@@H](C)OC=1C(=NC=C(N1)NC1=NC=C(C(=C1)OC)C=1C=NN(C1)C)C#N)C

InChiKey : IENLGMOXAQMNEH-CYBMUJFWSA-N

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SynonymsCCT244747; CCT-244747; 
Molecular FormulaC20H24N8O2 
Molecular Weight408.46 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileCN(C[C@@H](C)OC=1C(=NC=C(N1)NC1=NC=C(C(=C1)OC)C=1C=NN(C1)C)C#N)C
InChiKeyIENLGMOXAQMNEH-CYBMUJFWSA-N
InChiInChI=1S/C20H24N8O2/c1-13(11-27(2)3)30-20-16(7-21)22-10-19(26-20)25-18-6-17(29-5)15(9-23-18)14-8-24-28(4)12-14/h6,8-10,12-13H,11H2,1-5H3,(H,23,25,26)/t13-/m1/s1
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CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies. 

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