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CCT244747

Catalog No.: 16070913
Cas No.: 1404095-34-6
Purity : 98% by HPLC 

CCT244747 is a novel potent, highly selective, orally active ATP-competitive CHK1 inhibitor with potential anticancer activity. CCT244747 inhibited cellular CHK1 activity (IC(50) 29-170 nmol/L), significantly enhanced the cytotoxicity of several anticancer drugs, and abrogated drug-induced S and G(2) arrest in multiple tumor cell lines. CCT244747 represents the first structural disclosure of a highly selective, orally active CHK1 inhibitor and warrants further evaluation alone or combined with genotoxic anticancer therapies. 

For research use only. We do not sell to patients.

Chemical Information

NameCCT244747
Iupac Chemical Name(R)-3-((1-(dimethylamino)propan-2-yl)oxy)-5-((4-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-yl)amino)pyrazine-2-carbonitrile 
SynonymsCCT244747; CCT-244747; 
Molecular FormulaC20H24N8O2 
Molecular Weight408.46 
SmileCN(C[C@@H](C)OC=1C(=NC=C(N1)NC1=NC=C(C(=C1)OC)C=1C=NN(C1)C)C#N)C
InChiKeyIENLGMOXAQMNEH-CYBMUJFWSA-N
InChiInChI=1S/C20H24N8O2/c1-13(11-27(2)3)30-20-16(7-21)22-10-19(26-20)25-18-6-17(29-5)15(9-23-18)14-8-24-28(4)12-14/h6,8-10,12-13H,11H2,1-5H3,(H,23,25,26)/t13-/m1/s1
CAS Number1404095-34-6
Related CAS

Ordering Information

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FormulationSolid powder 
Purity98% by HPLC 
Storage-20 ºC for 3 years 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16070913 - CCT244747 | CAS 1404095-34-6

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