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CCG215022

Catalog No.: 16122914
Cas No.: 1813527-81-9
Purity : 98% 
16122914 - CCG215022 | CAS 1813527-81-9

Catalog number : 16122914

CAS number : 1813527-81-9

Molecular Formula : C26H22FN7O3 

Molecular Weight : 499.5064 

Iupac Chemical Name : CCG215022 

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SynonymsCCG 215022; CCG-215022 
Molecular FormulaC26H22FN7O3 
Molecular Weight499.5064 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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CCG215022 is a potent GRK2 and GRK5 inhibitor. CCG215022 exhibited nanomolar IC50 values against both GRK2 and GRK5 and good selectivity against other closely related kinases such as GRK1 and PKA. Treatment of murine cardiomyocytes with CCG215022 resulted in significantly increased contractility at 20-fold lower concentrations than paroxetine, an inhibitor with more modest selectivity for GRK2. G protein-coupled receptor kinases (GRKs) regulate cell signaling by initiating the desensitization of active G protein-coupled receptors. The two most widely expressed GRKs (GRK2 and GRK5) play a role in cardiovascular disease and thus represent important targets for the development of novel therapeutic drugs. 

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