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CC0651

Catalog No.: 611933
Cas No.: 1319207-44-7
Purity : 98% 

CC0651 is an allosteric inhibitor of the human cdc34 ubiquitin-conjugating enzyme that potently (IC50 = 1.72 uM) inhibited the ubiquitination of p27 Kip1.

CC0651 that potently (IC50 = 1.72 uM) inhibited the ubiquitination of p27 Kip1, as confrmed by dose-response analysis. CC0651 corresponds to (2R,3S,4S)-5-(3,5-dichlorobiphenyl-4-yl)-2,3-dihydroxy-4-(2-methoxyacetamido) pentanoic acid and has a molecular mass of 442.3 g/mol.The calculated Log P and Log D values for CC0651 were 2.46 and 0.985, with an aqueous solubility of 1 mg/ml at pH 7.4. CC0651 had no effect on ubiquitination of
the yeast CDK inhibitor Sic1 in the yeast Cdc34-SCF Cdc4 reaction. However, substitution of yeast Cdc34 with hCdc34 in this reaction caused CC0651 to robustly inhibit Sic1 ubiquitination.

 

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Chemical Information

NameCC0651
Iupac Chemical NameCC0651 
SynonymsCC 0651; CC-0651 
Molecular FormulaC20H21Cl2NO6 
Molecular Weight442.29 
InChiKey
InChi
CAS Number1319207-44-7
Related CAS

Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

611933 - CC0651 | CAS 1319207-44-7

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