+86-27-65522453 sales@sun-shinechem.com


Catalog No.: 203071
Cas No.: 1860875-51-9
Purity : 98% Min.
203071 - CC-90009 | CAS 1860875-51-9

Catalog number : 203071

CAS number : 1860875-51-9

Molecular Formula : C22H18ClF2N3O4

Molecular Weight : 461.85

Iupac Chemical Name : 2-(4-Chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide

Smile : ClC1=CC=C(C=C1)C(C(=O)NCC=1C=C2CN(C(C2=CC1)=O)C1C(NC(CC1)=O)=O)(F)F


PackagingPriceAvailabilityPurityEstimated Shipping Time
Request Bulk Quote Download MSDSTel:+86-27-65522453 | Email:sales@sun-shinechem.com
SynonymsCC-90009; CC 90009; CC90009
Molecular FormulaC22H18ClF2N3O4
Molecular Weight461.85
AppearanceOff-white solid to white solid
Purity98% Min.
SolubilitySoluble in DMSO, not in water
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature 
Coming soon.
CC-90009 is a
 modulator of cereblon (CRBN), which is part of the cullin 4-RING E3 ubiquitin ligase complex (CRL4-CRBN E3 ubiquitin ligase; CUL4-CRBN E3 ubiquitin ligase), with potential immunomodulating and pro-apoptotic activities. Upon administration, CC-90009 specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. This leads to the ubiquitination of certain substrate proteins and induces the proteasome-mediated degradation of certain transcription factors, including Ikaros (IKZF1) and Aiolos (IKZF3), which are transcriptional repressors in T-cells. This reduces the levels of these transcription factors, and modulates the activity of the immune system, which may include the activation of T-lymphocytes. In addition, this downregulates the expression of other proteins, including interferon regulatory factor 4 (IRF4) and c-myc, which plays a key role in the proliferation of certain cancer cell types. CRBN, the substrate recognition component of the E3 ubiquitin ligase complex, plays a key role in the ubiquitination of certain proteins.

1860875-51-9 - Request Bulk Quote

1860875-51-9 - Request Bulk Quote