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CB-839

Catalog No.: 16122913
Cas No.: 1439399-58-2
Purity : 98% 
16122913 - CB-839 | CAS 1439399-58-2

Catalog number : 16122913

CAS number : 1439399-58-2

Molecular Formula : C26H24F3N7O3S 

Molecular Weight : 571.57 

Iupac Chemical Name : CB-839 

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SynonymsCB839; CB-839; CB 839 
Molecular FormulaC26H24F3N7O3S 
Molecular Weight571.57 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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CB-839 an is orally bioavailable inhibitor of glutaminase, with potential antineoplastic activity. Upon oral administration, CB-839 selectively and irreversibly inhibits glutaminase, a mitochondrial enzyme that is essential for the conversion of the amino acid glutamine into glutamate. By blocking glutamine utilization, proliferation in rapidly growing cells is impaired. Glutamine-dependent tumors rely on the conversion of exogenous glutamine into glutamate and glutamate metabolites to both provide energy and generate building blocks for the production of macromolecules, which are needed for cellular growth and survival. 

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