CB-6644 acts as a noncompetitive ATPase inhibitor. Additionally, it can inhibit RUVBL1/2 ATPase activity without blocking nucleotide binding. CB-6644 also interacts with the RUVBL1/2 complex in cells and induces cancer Ramos cell death. Besides, CB-6644 binds to and stabilizes RUVBL1/2 in Ramos cells.
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