Welcome to Sun-shine chemical
+86-27-65522453 sales@sun-shinechem.com

CB-6644

Catalog No.: 41788
Cas No.: 2316817-88-4
Purity : 96.33%

CB-6644 acts as a noncompetitive ATPase inhibitor. Additionally, it can inhibit RUVBL1/2 ATPase activity without blocking nucleotide binding. CB-6644 also interacts with the RUVBL1/2 complex in cells and induces cancer Ramos cell death. Besides, CB-6644 binds to and stabilizes RUVBL1/2 in Ramos cells.

For research use only. We do not sell to patients.

Chemical Information

NameCB-6644
Iupac Chemical Name5-Chloro-2-ethoxy-4-fluoro-N-(4-((3-(methoxymethyl)-1-oxo-6,7-dihydro-1H,5H-benzo[c]pyrazolo[1,2-a][1,2]diazepin-2-yl)amino)-2,2-dimethyl-4-oxobutyl)benzamide
SynonymsCB-6644 ; CB 6644 ; CB6644
Molecular FormulaC29H34ClFN4O5
Molecular Weight573.0624
SmileO=C(NCC(C)(C)CC(NC(C1=O)=C(COC)N2N1C3=CC=CC=C3CCC2)=O)C4=CC(Cl)=C(F)C=C4OCC
InChiKeyVYCOZEBCSAQCES-UHFFFAOYSA-N
InChi InChI=1S/C29H34ClFN4O5/c1-5-40-24-14-21(31)20(30)13-19(24)27(37)32-17-29(2,3)15-25(36)33-26-23(16-39-4)34-12-8-10-18-9-6-7-11-22(18)35(34)28(26)38/h6-7,9,11,13-14H,5,8,10,12,15-17H2,1-4H3,(H,32,37)(H,33,36)
CAS Number2316817-88-4
Related CAS2316817-88-4

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS Tel : +86-27-65522453   Email : sales@sun-shinechem.com
FormulationSolid powder
Purity96.33%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
HandlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code2933999701
Coming soon.
TargetsRUVBL1/2 Complex Inhibitor
Mechanism
Cell study
Animal study
Clinical study

1: Assimon VA, Tang Y, Vargas JD, Lee GJ, Wu ZY, Lou K, Yao B, Menon MK, Pios A, Perez KC, Madriaga A, Buchowiecki PK, Rolfe M, Shawver L, Jiao X, Le Moigne R, Zhou HJ, Anderson DJ. CB-6644 Is a Selective Inhibitor of the RUVBL1/2 Complex with Anticancer Activity. ACS Chem Biol. 2019 Feb 15;14(2):236-244. doi: 10.1021/acschembio.8b00904. Epub 2019 Jan 25. PubMed PMID: 30640450.

Chemical Structure

41788 - CB-6644 | CAS 2316817-88-4

Quick inquiry

Change