CAY10505 is a phosphatidylinositol 3-kinase- inhibitor , was found to significantly improve acetylcholine-induced endothelium dependent relaxation, serum nitrate and (or) nitrite level, glutathione level, and the vascular endothelial lining in hypertensive rats. CAY10505 , may improve hypertension-associated vascular endothelial dysfunction. Inhibition of PI3K might be a useful approach in the therapeutics of vascular endothelium dysfunction.
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| Name | CAY10505 |
|---|---|
| Iupac Chemical Name | (E)-5-((5-(4-fluorophenyl)furan-2-yl)methylene)thiazolidine-2,4-dione |
| Synonyms | CAY10505; CAY 10505; CAY10505 |
| Molecular Formula | C14H8FNO3S |
| Molecular Weight | 289.28 |
| Smile | FC1=CC=C(C=C1)C1=CC=C(O1)\C=C\1/C(NC(S1)=O)=O |
| InChiKey | UFBTYTGRUBUUIL-KPKJPENVSA-N |
| InChi | InChI=1S/C14H8FNO3S/c15-9-3-1-8(2-4-9)11-6-5-10(19-11)7-12-13(17)16-14(18)20-12/h1-7H,(H,16,17,18)/b12-7+ |
| CAS Number | 1218777-13-9 |
| Related CAS |
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
| Targets | |
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| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |