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C-DIM12

Catalog No.: 16122915
Cas No.: 178946-89-9
Purity : 98% 
16122915 - C-DIM12 | CAS 178946-89-9

Catalog number : 16122915

CAS number : 178946-89-9

Molecular Formula : C23H17ClN2 

Molecular Weight : 356.853 

Iupac Chemical Name : C-DIM12 

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SynonymsC-DIM 12; C-DIM-12 
Molecular FormulaC23H17ClN2 
Molecular Weight356.853 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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C-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons. 

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