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Bimiralisib

Catalog No: 17030116
CAS Number: 1225037-39-7
Purity: 98% 

Bimiralisib, also known as PQR309, is an orally bioavailable pan inhibitor of phosphoinositide-3-kinases (PI3K) and inhibitor of the mammalian target of rapamycin (mTOR), with potential antineoplastic activity. PI3K/mTOR kinase inhibitor PQR309 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy. 

For research use only. We do not sell to patients.

Chemical Information

NameBimiralisib
Iupac Chemical Name5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine 
SynonymsPQR309; PQR-309; PQR309; Bimiralisib free base 
Molecular FormulaC17H20F3N7O2 
Molecular Weight411.3892 
SmileO1CCN(CC1)C1=NC(=NC(=N1)N1CCOCC1)C=1C(=CC(=NC1)N)C(F)(F)F
InChiKeyADGGYDAFIHSYFI-UHFFFAOYSA-N
InChiInChI=1S/C17H20F3N7O2/c18-17(19,20)12-9-13(21)22-10-11(12)14-23-15(26-1-5-28-6-2-26)25-16(24-14)27-3-7-29-8-4-27/h9-10H,1-8H2,(H2,21,22)
CAS Number1225037-39-7
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationoff-white solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

17030116 - Bimiralisib | CAS 1225037-39-7

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