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Belvarafenib

Catalog No.: 19341
Cas No.: 1446113-23-0
Purity : >98%
19341 - Belvarafenib | CAS 1446113-23-0

Catalog number : 19341

CAS number : 1446113-23-0

Molecular Formula : C23H18ClFN6OS

Molecular Weight : 480.94

Iupac Chemical Name : 4-amino-N-(1-((3-chloro-2-fluorophenyl)amino)-7-methyl-4a,8a-dihydroisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide

Smile : FC1=C(Cl)C=CC=C1NC2=NC=CC3C(NC(C4=CSC5=C4N=CN=C5N)=O)=CC(C)=CC23

InChiKey : PNKLALSHRLTGTH-UHFFFAOYSA-N

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SynonymsBelvarafenib; GDC-5573; GDC5573; GDC 5573; HM95573; HM 95573; HM-95573; RG6185; RG-6185; RG 6185;
Molecular FormulaC23H18ClFN6OS
Molecular Weight480.94
AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
SmileFC1=C(Cl)C=CC=C1NC2=NC=CC3C(NC(C4=CSC5=C4N=CN=C5N)=O)=CC(C)=CC23
InChiKeyPNKLALSHRLTGTH-UHFFFAOYSA-N
InChiInChI=1S/C23H18ClFN6OS/c1-11-7-13-12(5-6-27-22(13)30-16-4-2-3-15(24)18(16)25)17(8-11)31-23(32)14-9-33-20-19(14)28-10-29-21(20)26/h2-10,12-13H,1H3,(H,27,30)(H,31,32)(H2,26,28,29)
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Belvarafenib, also known as GDC-5573, HM95573, RG6185, is a selective inhibitor of the RAF family kinases designed to inhibit the MAPK pathway, which is frequently activated in human tumors and drives tumor growth.

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