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BP-1-102

Catalog No: 17030606
CAS Number: 1334493-07-0
Purity: 98% 

BP-1-102 is a potent, orally bioavailable and selective STAT3 inhibitor. BP-1-102 binds Stat3 with an affinity (K(D)) of 504 nM, blocks Stat3-phospho-tyrosine (pTyr) peptide interactions and Stat3 activation at 4-6.8 M, and selectively inhibits growth, survival, migration, and invasion of Stat3-dependent tumor cells. BP-1-102-mediated inhibition of aberrantly active Stat3 in tumor cells suppresses the expression of c-Myc, Cyclin D1, Bcl-xL, Survivin, VEGF, and Krüppel-like factor 8, which is identified as a Stat3 target gene that promotes Stat3-mediated breast tumor cell migration and invasion. 

For research use only. We do not sell to patients.

Chemical Information

NameBP-1-102
Iupac Chemical Name4-(N-(4-cyclohexylbenzyl)-2-(2,3,4,5,6-pentafluoro-N-methylphenylsulfonamido)acetamido)-2-hydroxybenzoic acid 
SynonymsBP-1-102; BP1-102; BP 1-102; BP1102; BP-1102; BP 1102 
Molecular FormulaC29H27F5N2O6S 
Molecular Weight626.59 
SmileC1(CCCCC1)C1=CC=C(CN(C(CN(S(=O)(=O)C2=C(C(=C(C(=C2F)F)F)F)F)C)=O)C2=CC(=C(C(=O)O)C=C2)O)C=C1
InChiKeyWNVSFFVDMUSXSX-UHFFFAOYSA-N
InChiInChI=1S/C29H27F5N2O6S/c1-35(43(41,42)28-26(33)24(31)23(30)25(32)27(28)34)15-22(38)36(19-11-12-20(29(39)40)21(37)13-19)14-16-7-9-18(10-8-16)17-5-3-2-4-6-17/h7-13,17,37H,2-6,14-15H2,1H3,(H,39,40)
CAS Number1334493-07-0
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Ordering Information

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Formulationoff-white solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

17030606 - BP-1-102 | CAS 1334493-07-0

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