BMS-582949
Catalog No: 16062903
CAS Number: 623152-17-0
Purity: 98% by HPLC
BMS-582949 is a potent and selective P38 mitogen-activated protein kinase (P38 MAPK) inhibitor. BMS-582949 is currently under Phase II clinical trials for the treatment of inflammatory diseases. One clinical study showed that, in stable atherosclerosis, 12 weeks of treatment with BMS-582949 did not reduce arterial inflammation or hs-CRP compared to placebo, whereas intensification of statin therapy significantly decreased arterial inflammation. p38 MAP kinase plays a crucial role in regulating the biosynthesis of many inflammatory cytokines including TNF and IL-1
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Chemical Information
| Name | BMS-582949 |
|---|---|
| Iupac Chemical Name | 4-((5-(cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide |
| Synonyms | BMS-582949; BMS 582949; |
| Molecular Formula | C22H26N6O2 |
| Molecular Weight | 406.49 |
| Smile | C1(CC1)NC(=O)C=1C=CC(=C(C1)NC1=NC=NN2C1=C(C(=C2)C(=O)NCCC)C)C |
| InChiKey | GDTQLZHHDRRBEB-UHFFFAOYSA-N |
| InChi | InChI=1S/C22H26N6O2/c1-4-9-23-22(30)17-11-28-19(14(17)3)20(24-12-25-28)27-18-10-15(6-5-13(18)2)21(29)26-16-7-8-16/h5-6,10-12,16H,4,7-9H2,1-3H3,(H,23,30)(H,26,29)(H,24,25,27) |
| CAS Number | 623152-17-0 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Solid powder |
|---|---|
| Purity | 98% by HPLC |
| Storage | -20 ºC for 3 years |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
