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BMS-3

Catalog No: 16071026
CAS Number: 1338247-30-5
Purity: 98% by HPLC 

 BMS-3 is a LIM kinase 1 (LIMK1) inhibitor. LIMK inhibition with 1 M BMS-3 damaged MTOC protein localisation to spindle poles, undermined the formation and positioning of functional MTOC and thus disrupted spindle formation and chromosome alignment. These effects were phenocopied by microinjection of LIMK1 antibody into mouse oocytes. LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression. 

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Chemical Information

NameBMS-3
Iupac Chemical NameN-[5-[2-(2,6-Dichlorophenyl)-5-(difluoromethyl)pyrazol-3-yl]-1,3-thiazol-2-yl]cyclopropanecarboxamide 
SynonymsBMS-3; BMS 3 
Molecular FormulaC17H12Cl2F2N4OS 
Molecular Weight429.2668 
SmileClC1=C(C(=CC=C1)Cl)N1N=C(C=C1C1=CN=C(S1)NC(=O)C1CC1)C(F)F
InChiKeyYBGGBHCJSAEIAS-UHFFFAOYSA-N
InChiInChI=1S/C17H12Cl2F2N4OS/c18-9-2-1-3-10(19)14(9)25-12(6-11(24-25)15(20)21)13-7-22-17(27-13)23-16(26)8-4-5-8/h1-3,6-8,15H,4-5H2,(H,22,23,26)
CAS Number1338247-30-5
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Ordering Information

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FormulationSolid powder 
Purity98% by HPLC 
Storage-20 ºC for 3 years 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

16071026 - BMS-3 | CAS 1338247-30-5

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