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BIX02188

Catalog No.: 122205
Cas No.: 334949-59-6
Purity : 98% 
122205 - BIX02188 | CAS 334949-59-6

Catalog number : 122205

CAS number : 334949-59-6

Molecular Formula : C25H24N4O2 

Molecular Weight : 412.48 

Iupac Chemical Name : (3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide 

Smile : O=C(C3=CC(NC2=O)=C(C=C3)/C2=C(NC4=CC=CC(CN(C)C)=C4)\C1=CC=CC=C1)N

InChiKey : FSZPIAXLCCQFCM-FCQUAONHSA-N

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SynonymsBIX 02188; BIX-02188 
Molecular FormulaC25H24N4O2 
Molecular Weight412.48 
AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileO=C(C3=CC(NC2=O)=C(C=C3)/C2=C(NC4=CC=CC(CN(C)C)=C4)\C1=CC=CC=C1)N
InChiKeyFSZPIAXLCCQFCM-FCQUAONHSA-N
InChiInChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,27H,15H2,1-2H3,(H2,26,30)(H,28,31)/b23-22-
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BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2. 

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