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BH3I-1

Catalog No.: 61402
Cas No.: 300817-68-9
Purity : 98% 
61402 - BH3I-1 | CAS 300817-68-9

Catalog number : 61402

CAS number : 300817-68-9

Molecular Formula : C15H14BrNO3S2 

Molecular Weight : 400.31 

Iupac Chemical Name : BH3I-1 

Smile : CC(C)C(C(=O)O)N1C(=O)/C(=C\c2ccc(cc2)Br)/SC1=S

InChiKey : COHIEJLWRGREHV-YRNVUSSQSA-N

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SynonymsBHI1; BHI-1; BHI 1; BH 3I1 
Molecular FormulaC15H14BrNO3S2 
Molecular Weight400.31 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCC(C)C(C(=O)O)N1C(=O)/C(=C\c2ccc(cc2)Br)/SC1=S
InChiKeyCOHIEJLWRGREHV-YRNVUSSQSA-N
InChiInChI=1S/C15H14BrNO3S2/c1-8(2)12(14(19)20)17-13(18)11(22-15(17)21)7-9-3-5-10(16)6-4-9/h3-8,12H,1-2H3,(H,19,20)/b11-7+
MDLMFCD03453544
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BH3I-1 is an inhibitor of Bcl-xL with IC 50 of 293.95 M. BH3I-1 is a cell permeable BH3 mimetic that binds to Bcl-xL, BH3I-1 can induce cell death. BH3I-1 is a bak activator


BH3I-1 can exerted an antineoplastic effect in thyroid carcinoma cells and sensitized to sublethal concentrations of doxorubicin and bortezomib.
BH3I-1 had a strong sensitizing effect on bortezomib-induced cell death.


 

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