+86-27-65522453 sales@sun-shinechem.com

BDA-366

Catalog No.: 17030305
Cas No.: 1821496-27-8
Purity : 98% 
17030305 - BDA-366 | CAS 1821496-27-8

Catalog number : 17030305

CAS number : 1821496-27-8

Molecular Formula : C24H29N3O4 

Molecular Weight : 423.513 

Iupac Chemical Name : 1-(((S)-3-(diethylamino)-2-hydroxypropyl)amino)-4-((((S)-oxiran-2-yl)methyl)amino)anthracene-9,10-dione 

Smile : C(C)N(C[C@H](CNC1=CC=C(C=2C(C3=CC=CC=C3C(C12)=O)=O)NC[C@@H]1OC1)O)CC

InChiKey : JYOOEVFJWLBLKF-HOTGVXAUSA-N

PackagingPriceAvailabilityPurityEstimated Shipping Time
BulkEnquiryEnquiry
Request Bulk Quote Download MSDSTel:+86-27-65522453 | Email:sales@sun-shinechem.com
SynonymsBDA-366; BDA 366; BDA366 
Molecular FormulaC24H29N3O4 
Molecular Weight423.513 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileC(C)N(C[C@H](CNC1=CC=C(C=2C(C3=CC=CC=C3C(C12)=O)=O)NC[C@@H]1OC1)O)CC
InChiKeyJYOOEVFJWLBLKF-HOTGVXAUSA-N
InChiInChI=1S/C24H29N3O4/c1-3-27(4-2)13-15(28)11-25-19-9-10-20(26-12-16-14-31-16)22-21(19)23(29)17-7-5-6-8-18(17)24(22)30/h5-10,15-16,25-26,28H,3-4,11-14H2,1-2H3/t15-,16-/m0/s1
Coming soon.
BDA-366 is a BCL2-BH4 antagonist. BDA-366 suppresses human myeloma growth. BDA-366 induces robust apoptosis in MM cell lines and primary MM cells by inducing BCL2 conformational change. Delivery of BDA-366 substantially suppressed the growth of human MM xenografts in NOD-scid/IL2Rnull mice, without significant cytotoxic effects on normal hematopoietic cells or body weight. Thus, BDA-366 functions as a novel BH4-based BCL2 inhibitor and offers an entirely new tool for MM therapy. 

1821496-27-8 - Request Bulk Quote

×
1821496-27-8 - Request Bulk Quote
Change