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BAM 7

Catalog No.: 16071006
Cas No.: 331244-89-4
Purity : 98% by HPLC 
16071006 - BAM 7 | CAS 331244-89-4

Catalog number : 16071006

CAS number : 331244-89-4

Molecular Formula : C21H19N5O2S 

Molecular Weight : 405.476 

Iupac Chemical Name : (E)-4-(2-(2-ethoxyphenyl)hydrazono)-5-methyl-2-(4-phenylthiazol-2-yl)-2,4-dihydro-3H-pyrazol-3-one 

Smile : C(C)OC1=C(C=CC=C1)N\N=C/1\C(N(N=C1C)C=1SC=C(N1)C1=CC=CC=C1)=O

InChiKey : KOCVKGYKBLJEPK-LYBHJNIJSA-N

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SynonymsBAM 7; BAM-7 
Molecular FormulaC21H19N5O2S 
Molecular Weight405.476 
AppearanceSolid powder 
Purity98% by HPLC 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileC(C)OC1=C(C=CC=C1)N\N=C/1\C(N(N=C1C)C=1SC=C(N1)C1=CC=CC=C1)=O
InChiKeyKOCVKGYKBLJEPK-LYBHJNIJSA-N
InChiInChI=1S/C21H19N5O2S/c1-3-28-18-12-8-7-11-16(18)23-24-19-14(2)25-26(20(19)27)21-22-17(13-29-21)15-9-5-4-6-10-15/h4-13,23H,3H2,1-2H3/b24-19+
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 BAM 7 is a Bax activator (EC50 = 3.3 M). BCL-2 family proteins are key regulators of the apoptotic pathway. Antiapoptotic members sequester the BCL-2 homology 3 (BH3) death domains of proapoptotic members such as BAX to maintain cell survival. The antiapoptotic BH3-binding groove has been successfully targeted to reactivate apoptosis in cancer. 

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