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Axitinib

Catalog No: 52771
CAS Number: 319460-85-0
Purity: 98% 

Axitinib, also known as AG013736, is an orally bioavailable tyrosine kinase inhibitor. Axitinib inhibits the proangiogenic cytokines vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor (PDGF), thereby exerting an anti-angiogenic effect. A xitinib has received FDA (27 January 2012), EMA (13 September 2012), MHRA (3 September 2012) and TGA (26 July 2012) approval for use as a treatment for renal cell carcinoma.

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Chemical Information

NameAxitinib
Molecular FormulaC22H18N4OS 
Molecular Weight386.47 
SmileCNC(=O)c1ccccc1Sc2ccc3c(c2)[nH]nc3/C=C/c4ccccn4
InChiKeyRITAVMQDGBJQJZ-FMIVXFBMSA-N
InChiInChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
CAS Number319460-85-0
MDLMFCD09837898
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Ordering Information

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Purity98% 
SolubilitySoluble to 25 mM in DMSO 
Handling
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

52771 - Axitinib | CAS 319460-85-0

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