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Asciminib

Catalog No.: 1711222
Cas No.: 1492952-76-7
Purity : >98%

Asciminib, also known as ABL001, is a potent allosteric inhibitor of BCR-ABL. ABL001 preventsemergence of resistant disease when administered in combination with nilotinib in an in vivo murinemodel of chronic myeloid leukemia.

For research use only. We do not sell to patients.

Chemical Information

NameAsciminib
Iupac Chemical Name(R)-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)nicotinamide
SynonymsABL-001; AB -001; ABL001; asciminib
Molecular FormulaC20H18ClF2N5O3
Molecular Weight449.8428
SmileO=C(NC1=CC=C(OC(F)(Cl)F)C=C1)C2=CN=C(N3C[C@H](O)CC3)C(C4=CC=NN4)=C2
InChiKeyVOVZXURTCKPRDQ-CQSZACIVSA-N
InChiInChI=1S/C20H18ClF2N5O3/c21-20(22,23)31-15-3-1-13(2-4-15)26-19(30)12-9-16(17-5-7-25-27-17)18(24-10-12)28-8-6-14(29)11-28/h1-5,7,9-10,14,29H,6,8,11H2,(H,25,27)(H,26,30)/t14-/m1/s1
CAS Number1492952-76-7
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Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationoff-white solid 
Purity>98%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO, not in water
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

1711222 - Asciminib | CAS 1492952-76-7

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