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Apitolisib(GDC-0980,RG7422)

Catalog No.: 62503
Cas No.: 1032754-93-0
Purity : >98% by HPLC 
62503 - Apitolisib(GDC-0980,RG7422) | CAS 1032754-93-0

Catalog number : 62503

CAS number : 1032754-93-0

Molecular Formula : C23H30N8O3S 

Molecular Weight : 498.6 

Iupac Chemical Name : (S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one 

Smile : NC1=NC=C(C=N1)C=1N=C(C2=C(N1)C(=C(S2)CN2CCN(CC2)C([C@H](C)O)=O)C)N2CCOCC2

InChiKey : YOVVNQKCSKSHKT-HNNXBMFYSA-N

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Molecular FormulaC23H30N8O3S 
Molecular Weight498.6 
Appearancesolid 
Purity>98% by HPLC 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature 
SmileNC1=NC=C(C=N1)C=1N=C(C2=C(N1)C(=C(S2)CN2CCN(CC2)C([C@H](C)O)=O)C)N2CCOCC2
InChiKeyYOVVNQKCSKSHKT-HNNXBMFYSA-N
InChiInChI=1S/C23H30N8O3S/c1-14-17(13-29-3-5-31(6-4-29)22(33)15(2)32)35-19-18(14)27-20(16-11-25-23(24)26-12-16)28-21(19)30-7-9-34-10-8-30/h11-12,15,32H,3-10,13H2,1-2H3,(H2,24,25,26)/t15-/m0/s1
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Apitolisib(GDC-0980,RG7422) is a dual PI3K/mTOR inhibitor.GDC-0980 was potent across a broad panel of cancer cell lines, with the greatest potency in breast, prostate, and lung cancers and less activity in melanoma and pancreatic cancers, consistent with KRAS and BRAF acting as resistance markers. 

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