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Apitolisib(GDC-0980,RG7422)

Catalog No: 62503
CAS Number: 1032754-93-0
Purity: >98% by HPLC 

Apitolisib(GDC-0980,RG7422) is a dual PI3K/mTOR inhibitor.GDC-0980 was potent across a broad panel of cancer cell lines, with the greatest potency in breast, prostate, and lung cancers and less activity in melanoma and pancreatic cancers, consistent with KRAS and BRAF acting as resistance markers. 

For research use only. We do not sell to patients.

Chemical Information

NameApitolisib(GDC-0980,RG7422)
Iupac Chemical Name(S)-1-(4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one 
Molecular FormulaC23H30N8O3S 
Molecular Weight498.6 
SmileNC1=NC=C(C=N1)C=1N=C(C2=C(N1)C(=C(S2)CN2CCN(CC2)C([C@H](C)O)=O)C)N2CCOCC2
InChiKeyYOVVNQKCSKSHKT-HNNXBMFYSA-N
InChiInChI=1S/C23H30N8O3S/c1-14-17(13-29-3-5-31(6-4-29)22(33)15(2)32)35-19-18(14)27-20(16-11-25-23(24)26-12-16)28-21(19)30-7-9-34-10-8-30/h11-12,15,32H,3-10,13H2,1-2H3,(H2,24,25,26)/t15-/m0/s1
CAS Number1032754-93-0
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Ordering Information

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Formulationsolid 
Purity>98% by HPLC 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature 
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

62503 - Apitolisib(GDC-0980,RG7422) | CAS 1032754-93-0

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