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Ampkinone

Catalog No.: 611810
Cas No.: 1233082-79-5
Purity : 98% 
611810 - Ampkinone | CAS 1233082-79-5

Catalog number : 611810

CAS number : 1233082-79-5

Molecular Formula : C31H23NO6 

Molecular Weight : 505.52 

Iupac Chemical Name : Ampkinone 

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Molecular FormulaC31H23NO6 
Molecular Weight505.52 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
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Ampkinone is a small molecule activator of AMPK; stimulate functional activation of AMPK via the phosphorylation at Thr172 in cultured L6 muscle cells with an EC50 value of 4.3 M, enhancing glucose uptake by 3.2-fold.


Ampkinone stimulated the phosphorylation of AMPK via the indirect activation of AMPK in various cell lines. Ampkinone-mediated activation of AMPK required the activity of LKB1 and resulted in increased glucose uptake in muscle cells. In addition, ampkinone-treated DIO mice significantly reduced total body weight and overall fat mass. Histological examination and measurement of lipid parameters showed that ampkinone effectively improved metabolic abnormalities in the DIO mice model.


 

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