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Ampkinone

Catalog No.: 611810
Cas No.: 1233082-79-5
Purity : 98% 

Ampkinone is a small molecule activator of AMPK; stimulate functional activation of AMPK via the phosphorylation at Thr172 in cultured L6 muscle cells with an EC50 value of 4.3 M, enhancing glucose uptake by 3.2-fold.


Ampkinone stimulated the phosphorylation of AMPK via the indirect activation of AMPK in various cell lines. Ampkinone-mediated activation of AMPK required the activity of LKB1 and resulted in increased glucose uptake in muscle cells. In addition, ampkinone-treated DIO mice significantly reduced total body weight and overall fat mass. Histological examination and measurement of lipid parameters showed that ampkinone effectively improved metabolic abnormalities in the DIO mice model.


 

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Chemical Information

NameAmpkinone
Iupac Chemical NameAmpkinone 
Molecular FormulaC31H23NO6 
Molecular Weight505.52 
InChiKey
InChi
CAS Number1233082-79-5
Related CAS

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

611810 - Ampkinone | CAS 1233082-79-5

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