Alixorexton
Catalog No: 25120
CAS Number: 2648347-56-0
Purity: 98% Min.
Alixorexton, also known as TAK-994 or firazorexton, is a potent, orally bioavailable, brain-penetrant agonist that selectively targets the orexin 2 receptor (OX2R), with additional activity at the orexin 1 receptor (OX1R). Its mechanism of action involves mimicking the endogenous orexin neuropeptides, thereby promoting wakefulness. Preclinical studies have demonstrated that Alixorexton effectively suppresses fragmentation of wakefulness and reduces cataplexy-like episodes in mouse models of narcolepsy, indicating its potential as a therapeutic agent for sleep disorders.
For research use only. We do not sell to patients.
Chemical Information
| Name | Alixorexton |
|---|---|
| Iupac Chemical Name | N-((21S,24S,52R,53S)-6-oxo-3,8-dioxa-5(2,1)-piperidina-1(1,2)-benzena-2(1,4)-cyclohexanacyclooctaphane-53-yl)methanesulfonamide |
| Synonyms | Alixorexton; firazorexton; TAK-994; TAK 994; TAK994; |
| Molecular Formula | C21H30N2O5S |
| Molecular Weight | 422.54 |
| Smile | O=C(N1[C@@]([H])(CO2)[C@](NS(=O)(C)=O)([H])CCC1)COC3=CC=CC=C3[C@]4([H])CC[C@@]2([H])CC4 |
| InChiKey | IHNJMACFBQEKRJ-NBMJBFSESA-N |
| InChi | InChI=1S/C21H30N2O5S/c1-29(25,26)22-18-6-4-12-23-19(18)13-27-16-10-8-15(9-11-16)17-5-2-3-7-20(17)28-14-21(23)24/h2-3,5,7,15-16,18-19,22H,4,6,8-14H2,1H3/t15-,16+,18-,19-/m0/s1 |
| CAS Number | 2648347-56-0 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
