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Alanosine

Catalog No.: 161227117
Cas No.: 5854-93-3
Purity : 98% 

Alanosine, also known as L-alanosine, is an amino acid analogue and antibiotic derived from the bacterium Streptomyces alanosinicus with antimetabolite and potential antineoplastic activities. L-alanosine inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate, an intermediate in purine metabolism. L-alanosine-induced disruption of de novo purine biosynthesis is potentiated by methylthioadenosine phosphorylase (MTAP) deficiency. The clinical use of this agent may be limited by its toxicity profile. MTAP is a key enzyme in the adenine and methionine salvage pathways. 

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Chemical Information

NameAlanosine
Iupac Chemical NameAlanosine 
SynonymsSDX102; SDX-102; SDX 102; alanosine; L-alanosine 
Molecular FormulaC3H7N3O4 
Molecular Weight149.11 
SmileN[C@@H](CN(O)N=O)C(=O)O
InChiKeyMLFKVJCWGUZWNV-REOHCLBHSA-N
InChiInChI=1S/C3H7N3O4/c4-2(3(7)8)1-6(10)5-9/h2,10H,1,4H2,(H,7,8)/t2-/m0/s1
CAS Number5854-93-3
Related CAS

Ordering Information

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Formulationcrystalline solid 
Purity98% 
Storage3 years -20ºCpowder 
SolubilitySoluble in DMSO 
Handling
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
HS Code
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Targets
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

161227117 - Alanosine | CAS 5854-93-3

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