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Akt1 and Akt2-IN-1

Catalog No.: 611804
Cas No.: 893422-47-4
Purity : 98% 
611804 - Akt1 and Akt2-IN-1 | CAS 893422-47-4

Catalog number : 611804

CAS number : 893422-47-4

Molecular Formula : C33H29N7O 

Molecular Weight : 539.63 

Chemical Name : Akt1 and Akt2-IN-1

Smile : c1ccc(cc1)c2cc3c(cc[nH]c3=O)nc2c4ccc(cc4)CN5CCC(CC5)c6nc([nH]n6)c7ccccn7

InChiKey : BTUWHHFNOHVCMQ-UHFFFAOYSA-N

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SynonymsAkt1 and Akt2-IN-1 
Molecular FormulaC33H29N7O 
Molecular Weight539.63 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Smilec1ccc(cc1)c2cc3c(cc[nH]c3=O)nc2c4ccc(cc4)CN5CCC(CC5)c6nc([nH]n6)c7ccccn7
InChiKeyBTUWHHFNOHVCMQ-UHFFFAOYSA-N
InChiInChI=1S/C33H29N7O/c41-33-27-20-26(23-6-2-1-3-7-23)30(36-28(27)13-17-35-33)24-11-9-22(10-12-24)21-40-18-14-25(15-19-40)31-37-32(39-38-31)29-8-4-5-16-34-29/h1-13,16-17,20,25H,14-15,18-19,21H2,(H,35,41)(H,37,38,39)
MDLMFCD13184803
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Akt1 and Akt2-IN-1 is an allosteric inhibitor of Akt1 (IC50 = 3.5 nM) and Akt2 (IC50 = 42 nM), with potent and balanced activity. Akt1 and Akt2-IN-1 has moderate activity in an hERG binding assay (IC50 = 5610 nM) and is a substrate for human P-glycoprotein (MDR1 Directional Transport Ratio (B to A/A to B) = 17.6). Akt1 and Akt2-IN-1 also shows good physical properties with a human plasma protein binding of 97.3% and a logP = 3.51.
 

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