Acoramidis是一种口服、强效、高选择性小分子转甲状腺素蛋白(TTR)稳定剂,旨在模拟具有保护作用的转甲状腺素蛋白(TTR)T119M突变的功能,维持TTR蛋白的正常四聚体构象,从而阻止具有毒性的淀粉样蛋白的产生。
For research use only. We do not sell to patients.
Name | Acoramidis hydrochloride |
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Iupac Chemical Name | 3-(3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy)-4-fluorobenzoic acid hydrochloride |
Synonyms | Acoramidis hydrochloride ; AG-10 hydrochloride ; AG10 hydrochloride; AG 10 hydrochloride |
Molecular Formula | C15H18ClFN2O3 |
Molecular Weight | 328.77 |
Smile | O=C(O)C1=CC=C(F)C(OCCCC2=C(C)NN=C2C)=C1.[H]Cl |
InChiKey | MGFZEARHINUOMX-UHFFFAOYSA-N |
InChi | InChI=1S/C15H17FN2O3.ClH/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16;/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20);1H |
CAS Number | 2242751-53-5 |
Related CAS | 2242751-53-5 |
Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | 类白色固体 |
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Purity | ≧98.0% |
Storage | 0-4℃,可保存几天到几周;-20℃,可保存 几个月。 |
Solubility | 溶于DMSO (DMSO : ≥ 100 mg/mL) |
Handling | Refer to MSDS |
Shipping Condition | 可以在室温下进行运输。 |
HS Code | 2934200090 |
Targets | transthyretin (TTR) stabilizer |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |