Welcome to Sun-shine chemical
+86-27-65522453 sales@sun-shinechem.com

Abrocitinib

Catalog No.: 19381
Cas No.: 1622902-68-4
Purity : >98%

Abrocitinib, Bulk in stock, contact us by email for the quotation. Kg scale intermediates are also be provided by custom synthesis.

Abrocitinib is an oral small molecule that selectively inhibits Janus kinase (JAK) 1. Inhibition of JAK1 is thought to modulate multiple cytokines involved in pathophysiology of atopic dermatitis, including interleukin (IL)-4, IL-13, IL-31, IL-22, and thymic stromal lymphopoietin (TSLP).

For research use only. We do not sell to patients.

Chemical Information

NameAbrocitinib
Iupac Chemical NameN-((1s,3s)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide
SynonymsPF-04965842; PF 04965842; PF04965842; Abrocitinib;
Molecular FormulaC14H21N5O2S
Molecular Weight323.41
SmileCCCS(=O)(N[C@H]1C[C@@H](N(C)C2=C3C(NC=C3)=NC=N2)C1)=O
InChiKeyIUEWXNHSKRWHDY-PHIMTYICSA-N
InChiInChI=1S/C14H21N5O2S/c1-3-6-22(20,21)18-10-7-11(8-10)19(2)14-12-4-5-15-13(12)16-9-17-14/h4-5,9-11,18H,3,6-8H2,1-2H3,(H,15,16,17)/t10-,11+
CAS Number1622902-68-4
Related CAS2204280-33-9 (trans-isomer) 1622902-68-4 (cis-isomer)

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS Tel : +86-27-65522453   Email : sales@sun-shinechem.com
FormulationOff-white solid to white solid
Purity>98%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
Handling
Shipping ConditionShipped under ambient temperature
HS Code
Coming soon.
Targets
Mechanism
Cell study
Animal study
Clinical study

[1]. Vazquez ML, et al. Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases. J Med Chem. 2018 Feb 8;61(3):1130-1152.

Chemical Structure

19381 - Abrocitinib | CAS 1622902-68-4

Quick inquiry

Change