AZD7507是一种有效的选择性CSF-1R抑制剂(32 nM 细胞活性), AZD7507被认为是一种很有前途的化合物,因为它保留了AZ683的预期药效和口服药代动力学特性。
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Name | AZD7507 |
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Iupac Chemical Name | 4-(2-fluoro-4-methylanilino)-6-[4-(2-hydroxyethyl)piperazin-1-yl]-7-methoxycinnoline-3-carboxamide |
Synonyms | AZD7507; AZD-7507; AZD 7507. |
Molecular Formula | C23H27FN6O3 |
Molecular Weight | 454.5064 |
Smile | O=C(C1=NN=C2C=C(OC)C(N3CCN(CCO)CC3)=CC2=C1NC4=CC=C(C)C=C4F)N |
InChiKey | CPDGCAFPSYOTGO-UHFFFAOYSA-N |
InChi | InChI=1S/C23H27FN6O3/c1-14-3-4-17(16(24)11-14)26-21-15-12-19(30-7-5-29(6-8-30)9-10-31)20(33-2)13-18(15)27-28-22(21)23(25)32/h3-4,11-13,31H,5-10H2,1-2H3,(H2,25,32)(H,26,27) |
CAS Number | 1041852-85-0 |
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Packaging | Price | Availability | Purity | Shipping Time |
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Bulk | Enquiry | Enquiry | Enquiry |
Formulation | 类白色至白色固体 |
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Purity | >98% |
Storage | 短期可在0-4度保存,数天至数月;长期可在-20度保存三年。 |
Solubility | 可溶于DMSO |
Handling | |
Shipping Condition | 可在常温下运输 |
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Mechanism | |
Cell study | |
Animal study | |
Clinical study |