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AZD6482 (S-isomer)

Catalog No.: 17011901
Cas No.: 1173900-37-2
Purity : 98% 
17011901 - AZD6482 (S-isomer) | CAS 1173900-37-2

Catalog number : 17011901

CAS number : 1173900-37-2

Molecular Formula : C22H24N4O4 

Molecular Weight : 408.458 

Iupac Chemical Name : (S)-2-((1-(7-methyl-2-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethyl)amino)benzoic acid 

Smile : CC=1C=C(C=2N(C(C=C(N2)N2CCOCC2)=O)C1)[C@H](C)NC1=C(C(=O)O)C=CC=C1

InChiKey : IRTDIKMSKMREGO-HNNXBMFYSA-N

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SynonymsAZD6482 (S); AZD6482; AZD-6482; AZD 6482 
Molecular FormulaC22H24N4O4 
Molecular Weight408.458 
Appearancecrystalline solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileCC=1C=C(C=2N(C(C=C(N2)N2CCOCC2)=O)C1)[C@H](C)NC1=C(C(=O)O)C=CC=C1
InChiKeyIRTDIKMSKMREGO-HNNXBMFYSA-N
InChiInChI=1S/C22H24N4O4/c1-14-11-17(15(2)23-18-6-4-3-5-16(18)22(28)29)21-24-19(12-20(27)26(21)13-14)25-7-9-30-10-8-25/h3-6,11-13,15,23H,7-10H2,1-2H3,(H,28,29)/t15-/m0/s1
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AZD6482 is a potent, selective and ATP competitive PI3K inhibitor (IC(50) 0.01 μm). AZD6482 inhibited insulin-induced human adipocyte glucose uptake in vitro (IC(50) of 4.4 μm). This is the first human target validation for PI3K inhibition as anti-platelet therapy showing a mild and generalized antiplatelet effect attenuating but not completely inhibiting multiple signaling pathways with an impressive separation towards primary hemostasis. AZD6482 at 'supratherapeutic' plasma concentrations may attenuate insulin signaling, most likely through PI3K inhibition. 

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