+86-27-65522453 sales@sun-shinechem.com

AZD3839

Catalog No.: 17022710
Cas No.: 1227163-56-5
Purity : 98% 
17022710 - AZD3839 | CAS 1227163-56-5

Catalog number : 17022710

CAS number : 1227163-56-5

Molecular Formula : C24H16F3N5 

Molecular Weight : 431.4222 

Iupac Chemical Name : (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine 

Smile : FC(C1=NC=CC(=C1)[C@@]1(N=C(C2=C(C=CC=C12)F)N)C1=CC(=CC=C1)C=1C=NC=NC1)F

InChiKey : MRXBCEQZNKUUIP-DEOSSOPVSA-N

PackagingPriceAvailabilityPurityEstimated Shipping Time
BulkEnquiryEnquiry
Request Bulk Quote Download MSDSTel:+86-27-65522453 | Email:sales@sun-shinechem.com
SynonymsN/A 
Molecular FormulaC24H16F3N5 
Molecular Weight431.4222 
Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
SmileFC(C1=NC=CC(=C1)[C@@]1(N=C(C2=C(C=CC=C12)F)N)C1=CC(=CC=C1)C=1C=NC=NC1)F
InChiKeyMRXBCEQZNKUUIP-DEOSSOPVSA-N
InChiInChI=1S/C24H16F3N5/c25-19-6-2-5-18-21(19)23(28)32-24(18,17-7-8-31-20(10-17)22(26)27)16-4-1-3-14(9-16)15-11-29-13-30-12-15/h1-13,22H,(H2,28,32)/t24-/m0/s1
Coming soon.
AZD3839 is a potent and selective BACE1 inhibitor. AZD3839 is clinical candidate for the treatment of Alzheimer disease. AZD3839 inhibits BACE1 activity, A and sAPP release from modified and wild-type human SH-SY5Y cells and mouse N2A cells as well as from mouse and guinea pig primary cortical neurons. Selectivity against BACE2 and cathepsin D was 14 and >1000-fold, respectively. AZD3839 exhibits dose- and time-dependent lowering of plasma, brain, and cerebrospinal fluid A levels in mouse, guinea pig, and non-human primate. AZD3839 effectively reduces the levels of A in brain, CSF, and plasma in several preclinical species. 

1227163-56-5 - Request Bulk Quote

×
1227163-56-5 - Request Bulk Quote
Change