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AZD3229

Catalog No.: 191287
Cas No.: 2248003-60-1
Purity : >98%
191287 - AZD3229 | CAS 2248003-60-1

Catalog number : 191287

CAS number : 2248003-60-1

Molecular Formula : C24H26FN7O3

Molecular Weight : 479.5164

Iupac Chemical Name : N-{4-[(6,7-dimethoxyquinazolin-4-yl)oxy]phenyl}-2-[4-(propan-2-yl)-1H-1,2,3-triazol-1-yl]acetamide

Smile : O=C(NC1=CC=C(NC2=C3C(F)=CC(OCCOC)=CC3=NC=N2)C=C1)CN4N=NC(C(C)C)=C4

InChiKey : FLJOFQUXYAWOPE-UHFFFAOYSA-N

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SynonymsAZD3229; AZD-3229; AZD 3229;
Molecular FormulaC24H26FN7O3
Molecular Weight 479.5164
AppearanceOff-white solid to white solid
Purity>98%
SolubilitySoluble in DMSO
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Shipping ConditionShipped under ambient temperature
SmileO=C(NC1=CC=C(NC2=C3C(F)=CC(OCCOC)=CC3=NC=N2)C=C1)CN4N=NC(C(C)C)=C4
InChiKeyFLJOFQUXYAWOPE-UHFFFAOYSA-N
InChiInChI=1S/C24H26FN7O3/c1-15(2)21-12-32(31-30-21)13-22(33)28-16-4-6-17(7-5-16)29-24-23-19(25)10-18(35-9-8-34-3)11-20(23)26-14-27-24/h4-7,10-12,14-15H,8-9,13H2,1-3H3,(H,28,33)(H,26,27,29)
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AZD3229 is a potent pan-KIT mutant inhibitor for the treatment of gastrointestinal stromal tumors. AZD3229 demonstrates potent single digit nM growth inhibition across a broad cell panel, with good margin to KDR-driven effects.

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