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AZD2858

Catalog No.: 122838
Cas No.: 486424-20-8
Purity : 98% 
122838 - AZD2858 | CAS 486424-20-8

Catalog number : 122838

CAS number : 486424-20-8

Molecular Formula : C21H23N7O3S 

Molecular Weight : 453.517 

Iupac Chemical Name : 3-amino-6-[4-(4-methylpiperazin-1-yl)sulfonylphenyl]-N-pyridin-3-ylpyrazine-2-carboxamide 

Smile : CN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C3=CN=C(C(=N3)C(=O)NC4=CN=CC=C4)N

InChiKey : FHCSBLWRGCOVPT-UHFFFAOYSA-N

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SynonymsAZD 2858; AZD-2858 
Molecular FormulaC21H23N7O3S 
Molecular Weight453.517 
AppearanceSolid powder 
Purity98% 
SolubilitySoluble in DMSO 
Storage-20 ºC for 3 years 
Shipping ConditionShipped under ambient temperature 
SmileCN1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C3=CN=C(C(=N3)C(=O)NC4=CN=CC=C4)N
InChiKeyFHCSBLWRGCOVPT-UHFFFAOYSA-N
InChiInChI=1S/C21H23N7O3S/c1-27-9-11-28(12-10-27)32(30,31)17-6-4-15(5-7-17)18-14-24-20(22)19(26-18)21(29)25-16-3-2-8-23-13-16/h2-8,13-14H,9-12H2,1H3,(H2,22,24)(H,25,29)
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AZD2858 is a selective GSK-3 inhibitor with an IC50 of 68 nM, inhibits tau phosphorylation at the S396 site, activates Wnt signaling pathway. 

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