AWZ1066S
AWZ1066S is a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis. AWZ1066S shows superior efficacy to existing anti-Wolbachia therapies in validated preclinical models of infection and has DMPK characteristics that are compatible with a short therapeutic regimen of 7 days or less. This candidate molecule is well-positioned for onward development and has the potential to make a significant impact on communities affected by filariasis.
For research use only. We do not sell to patients.
化学信息
| 名称 | AWZ1066S |
|---|---|
| Iupac 化学名称 | (S)-2-(3-methylmorpholino)-N-((2-(trifluoromethyl)pyridin-3-yl)methyl)pyrido[2,3-d]pyrimidin-4-amine |
| 同义词 | AWZ1066S; AWZ-1066S; AWZ 1066S; AWZ106S; AWZ-1066; AWZ 1066; |
| 分子式 | C19H19F3N6O |
| 分子量 | 404.3972 |
| Smile | FC(C1=NC=CC=C1CNC2=C(C=CC=N3)C3=NC(N4[C@@H](C)COCC4)=N2)(F)F |
| InChiKey | IZFVCNUAPFSNCO-LBPRGKRZSA-N |
| InChi | InChI=1S/C19H19F3N6O/c1-12-11-29-9-8-28(12)18-26-16-14(5-3-7-24-16)17(27-18)25-10-13-4-2-6-23-15(13)19(20,21)22/h2-7,12H,8-11H2,1H3,(H,24,25,26,27)/t12-/m0/s1 |
| Cas号 | 239272-16-1 |
| Related CAS |
订购信息
| Packaging | 价格 | Availability | 纯度 | Shipping Time |
|---|---|---|---|---|
| Bulk | 询价 | 询价 | 询价 |
| Formulation | Solid powder |
|---|---|
| 纯度 | 98% Min. |
| 存储 | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| 可溶性 | Soluble in DMSO |
| Handling | |
| 运输条件 | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1: Hong WD, Benayoud F, Nixon GL, Ford L, Johnston KL, Clare RH, Cassidy A, Cook
DAN, Siu A, Shiotani M, Webborn PJH, Kavanagh S, Aljayyoussi G, Murphy E, Steven
A, Archer J, Struever D, Frohberger SJ, Ehrens A, Hübner MP, Hoerauf A, Roberts
AP, Hubbard ATM, Tate EW, Serwa RA, Leung SC, Qie L, Berry NG, Gusovsky F,
Hemingway J, Turner JD, Taylor MJ, Ward SA, O'Neill PM. AWZ1066S, a highly
specific anti-Wolbachia drug candidate for a short-course treatment of
filariasis. Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1414-1419. doi:
10.1073/pnas.181658511
