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AV-412 Catalog No : 112101

Chemical Information

Product NameAV-412
Iupac Chemical NameN-(4-((3-chloro-4-fluorophenyl)amino)-7-(3-methyl-3-(4-methylpiperazin-1-yl)but-1-yn-1-yl)quinazolin-6-yl)acrylamide 
SynonymsAV412,AV 412,MP412,MP-412 
Molecular FormulaC27H28ClFN6O 
Molecular Weight507.00 
SmileC=CC(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1C#CC(N4CCN(C)CC4)(C)C)=O
InChiKeyZAJXXUDARPGGOC-UHFFFAOYSA-N
InChiInChI=1S/C27H28ClFN6O/c1-5-25(36)33-23-16-20-24(30-17-31-26(20)32-19-6-7-22(29)21(28)15-19)14-18(23)8-9-27(2,3)35-12-10-34(4)11-13-35/h5-7,14-17H,1,10-13H2,2-4H3,(H,33,36)(H,30,31,32)
Cas451492-95-8

Technical Data

Appearancelight-yellow solid to off-white solid 
Purity99.38% by HPLC at 254nm 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 6 months-80ºCin solvent 
Shipping ConditionShipped under ambient temperature. 
Quality control HNMR HPLC

Description

AV-412 is an EGFR/HER2 inhibitor that binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis.

 

Chemical Structure

112101 - AV-412 | CAS 451492-95-8

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