AV-412 Tosylate
Catalog No: 17030105
CAS Number: 451493-31-5
Purity: 98%
AV-412, also known as MP-412, is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization.
For research use only. We do not sell to patients.
Chemical Information
| Name | AV-412 Tosylate |
|---|---|
| Iupac Chemical Name | AV-412 Tosylate |
| Synonyms | MP-412; MP 412; MP412; AV-412; AV 412; AV412 |
| Molecular Formula | C41H44ClFN6O7S2 |
| Molecular Weight | 850.24 |
| Smile | Cc1ccc(cc1)S(=O)(=O)O.Cc1ccc(cc1)S(=O)(=O)O.CC(C)(C#Cc1cc2c(cc1NC(=O)C=C)c(ncn2)Nc3ccc(c(c3)Cl)F)N4CCN(CC4)C |
| InChiKey | GTWJVFFZCKODEV-UHFFFAOYSA-N |
| InChi | InChI=1S/C27H28ClFN6O.2C7H8O3S/c1-5-25(36)33-23-16-20-24(30-17-31-26(20)32-19-6-7-22(29)21(28)15-19)14-18(23)8-9-27(2,3)35-12-10-34(4)11-13-35;2*1-6-2-4-7(5-3-6)11(8,9)10/h5-7,14-17H,1,10-13H2,2-4H3,(H,33,36)(H,30,31,32);2*2-5H,1H3,(H,8,9,10) |
| CAS Number | 451493-31-5 |
| MDL | MFCD16038940 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | yellow solid |
|---|---|
| Purity | 98% |
| Storage | 3 years -20ºCpowder |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
