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AV-412 Tosylate Catalog No : 17030105

Chemical Information

Product NameAV-412 Tosylate
Iupac Chemical NameAV-412 Tosylate 
SynonymsMP-412; MP 412; MP412; AV-412; AV 412; AV412 
Molecular FormulaC41H44ClFN6O7S2 
Molecular Weight850.24 
SmileCc1ccc(cc1)S(=O)(=O)O.Cc1ccc(cc1)S(=O)(=O)O.CC(C)(C#Cc1cc2c(cc1NC(=O)C=C)c(ncn2)Nc3ccc(c(c3)Cl)F)N4CCN(CC4)C
InChiKeyGTWJVFFZCKODEV-UHFFFAOYSA-N
InChiInChI=1S/C27H28ClFN6O.2C7H8O3S/c1-5-25(36)33-23-16-20-24(30-17-31-26(20)32-19-6-7-22(29)21(28)15-19)14-18(23)8-9-27(2,3)35-12-10-34(4)11-13-35;2*1-6-2-4-7(5-3-6)11(8,9)10/h5-7,14-17H,1,10-13H2,2-4H3,(H,33,36)(H,30,31,32);2*2-5H,1H3,(H,8,9,10)
Cas451493-31-5
MDLMFCD16038940

Technical Data

Appearanceoff-white solid 
Purity98% 
SolubilitySoluble in DMSO 
Storage3 years -20ºCpowder 
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. 
Quality control

Description

AV-412, also known as MP-412, is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. 

Chemical Structure

17030105 - AV-412 Tosylate | CAS 451493-31-5

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