ASN007
Catalog No: 20103001
CAS Number: 2055597-12-9
Purity: ≧98.0%
ASN007 , a novel oral ERK inhibitor , has shown anti-tumor activity in both solid tumors and lymphoma models with BRAF and RAS mutations and also in a melanoma PDX model resistant to BRAF and MEK inhibitors.
For research use only. We do not sell to patients.
Chemical Information
| Name | ASN007 |
|---|---|
| Iupac Chemical Name | (S)-N-(2-amino-1-(3-chloro-5-fluorophenyl)ethyl)-1-(5-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1H-imidazole-4-carboxamide |
| Synonyms | ASN007; ASN-007; ASN 007; |
| Molecular Formula | C22H25ClFN7O2 |
| Molecular Weight | 473.9374 |
| Smile | CC1=CN=C(NC2CCOCC2)N=C1N3C=NC(C(N[C@H](CN)C4=CC(F)=CC(Cl)=C4)=O)=C3 |
| InChiKey | PWHIUQBBGPGFFV-GOSISDBHSA-N |
| InChi | InChI=1S/C22H25ClFN7O2/c1-13-10-26-22(28-17-2-4-33-5-3-17)30-20(13)31-11-19(27-12-31)21(32)29-18(9-25)14-6-15(23)8-16(24)7-14/h6-8,10-12,17-18H,2-5,9,25H2,1H3,(H,29,32)(H,26,28,30)/t18-/m1/s1 |
| CAS Number | 2055597-12-9 |
| Related CAS | 2055596-76-2 (racemic) 2055597-12-9 (free base) |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid to white solid |
|---|---|
| Purity | ≧98.0% |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | Avoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation. |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | ERK inhibitor |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Not available
Chemical Structure
