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ASN007

Catalog No.: 20103001
Cas No.: 2055597-12-9
Purity : ≧98.0%

 ASN007 , a novel oral ERK inhibitor , has shown anti-tumor activity in both solid tumors and lymphoma models with BRAF and RAS mutations and also in a melanoma PDX model resistant to BRAF and MEK inhibitors. 

For research use only. We do not sell to patients.

Chemical Information

NameASN007
Iupac Chemical Name(S)-N-(2-amino-1-(3-chloro-5-fluorophenyl)ethyl)-1-(5-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1H-imidazole-4-carboxamide
SynonymsASN007; ASN-007; ASN 007;
Molecular FormulaC22H25ClFN7O2
Molecular Weight473.9374
SmileCC1=CN=C(NC2CCOCC2)N=C1N3C=NC(C(N[C@H](CN)C4=CC(F)=CC(Cl)=C4)=O)=C3
InChiKeyPWHIUQBBGPGFFV-GOSISDBHSA-N
InChiInChI=1S/C22H25ClFN7O2/c1-13-10-26-22(28-17-2-4-33-5-3-17)30-20(13)31-11-19(27-12-31)21(32)29-18(9-25)14-6-15(23)8-16(24)7-14/h6-8,10-12,17-18H,2-5,9,25H2,1H3,(H,29,32)(H,26,28,30)/t18-/m1/s1
CAS Number2055597-12-9
Related CAS2055596-76-2 (racemic) 2055597-12-9 (free base)

Ordering Information

PackagingPriceAvailabilityPurityShipping Time
BulkEnquiryEnquiryEnquiry
Request Bulk Quote Download MSDS Tel : +86-27-65522453   Email : sales@sun-shinechem.com
FormulationOff-white solid to white solid
Purity≧98.0%
StorageDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
SolubilitySoluble in DMSO
HandlingAvoid inhalation, contact with eyes and skin. Avoid dust and aerosol formation. Use only in areas with appropriate exhaust ventilation.
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
HS Code
Coming soon.
TargetsERK inhibitor
Mechanism
Cell study
Animal study
Clinical study
Not available

Chemical Structure

20103001 - ASN007 | CAS 2055597-12-9

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