APS6-45
Catalog No: 25159
CAS Number: 2188236-41-9
Purity: 98% Min.
APS6-45 is a tumor calibrated inhibitor, showing unique polypharmacology. APS6-45 shows strongly improved therapeutic index in fly and human MTC xenograft models.
For research use only. We do not sell to patients.
Chemical Information
| Name | APS6-45 |
|---|---|
| Iupac Chemical Name | 4-(4-(3-(2-Fluoro-5-(perfluoropropan-2-yl)phenyl)ureido)phenoxy)-N-methylpicolinamide |
| Synonyms | APS6-45; APS645; APS6 45; APS-645; APS 645 |
| Molecular Formula | C23H16F8N4O3 |
| Molecular Weight | 548.39 |
| Smile | O=C(NC)C1=NC=CC(OC2=CC=C(NC(NC3=CC(C(C(F)(F)F)(F)C(F)(F)F)=CC=C3F)=O)C=C2)=C1 |
| InChiKey | MVUPJRHPAMCBQJ-UHFFFAOYSA-N |
| InChi | InChI=1S/C23H16F8N4O3/c1-32-19(36)18-11-15(8-9-33-18)38-14-5-3-13(4-6-14)34-20(37)35-17-10-12(2-7-16(17)24)21(25,22(26,27)28)23(29,30)31/h2-11H,1H3,(H,32,36)(H2,34,35,37) |
| CAS Number | 2188236-41-9 |
| Related CAS |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white solid |
|---|---|
| Purity | 98% Min. |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO |
| Handling | |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code |
Coming soon.
| Targets | |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
Sonoshita M, Scopton AP, Ung PMU, Murray MA, Silber L, Maldonado AY, Real A, Schlessinger A, Cagan RL, Dar AC. A whole-animal platform to advance a clinical kinase inhibitor into new disease space. Nat Chem Biol. 2018 Mar;14(3):291-298. doi: 10.1038/nchembio.2556. Epub 2018 Jan 22. PMID: 29355849; PMCID: PMC5931369.
Chemical Structure
