AMG-193
Catalog No: 24017
CAS Number: 2790567-82-5
Purity: 98.62%; EE 98.28%
AMG-193 is an oral, small-molecule, methylthioadenosine-cooperative inhibitor of the PRMT5 enzyme.
For research use only. We do not sell to patients.
Chemical Information
| Name | AMG-193 |
|---|---|
| Iupac Chemical Name | (4-Amino-1,3-dihydrofuro[3,4-c][1,7]naphthyridin-8-yl)[(3S)-3-[4-(trifluoromethyl)phenyl]morpholin-4-yl]methanone |
| Synonyms | AMG-193 ; AMG193 ; AMG 193 |
| Molecular Formula | C22H19F3N4O3 |
| Molecular Weight | 444.406 |
| Smile | O=C(C1=NC=C2N=C(N)C(COC3)=C3C2=C1)N4[C@@H](C5=CC=C(C(F)(F)F)C=C5)COCC4 |
| InChiKey | BFEBTMFPRJPBTK-LJQANCHMSA-N |
| InChi | InChI=1S/C22H19F3N4O3/c23-22(24,25)13-3-1-12(2-4-13)19-11-31-6-5-29(19)21(30)17-7-14-15-9-32-10-16(15)20(26)28-18(14)8-27-17/h1-4,7-8,19H,5-6,9-11H2,(H2,26,28)/t19-/m1/s1 |
| CAS Number | 2790567-82-5 |
| Related CAS | 2790567-82-5 |
Ordering Information
| Packaging | Price | Availability | Purity | Shipping Time |
|---|---|---|---|---|
| Bulk | Enquiry | Enquiry | Enquiry |
| Formulation | Off-white to light-yellow solid |
|---|---|
| Purity | 98.62%; EE 98.28% |
| Storage | Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years). |
| Solubility | Soluble in DMSO (DMSO : ≥ 100 mg/mL) |
| Handling | Refer to MSDS |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| HS Code | 2934200090 |
Coming soon.
| Targets | Protein arginine methyltransferase 5 (PRMT5) |
|---|---|
| Mechanism | |
| Cell study | |
| Animal study | |
| Clinical study |
1. ClinicalTrials.gov (NCT05094336) A Phase 1/1b/2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of AMG 193 Alone and in Combination With Docetaxel in Subjects With Advanced MTAP-null Solid Tumors. U.S.National Institutes of Health.
2. AMG 193 Effective in Multiple Tumor Types. Cancer Discov. 2023 Dec 12;13(12):2492.
Chemical Structure
